Because the Lot flows diagonally across France, most motorways heading from the Channel Ports in northern or western France lead directly to or connect with those leading to the area (A75, A20, A62). The motorway journey from, say, Calais would take from about 7h30 into the heart of the Valley.
International airports in/close to the area at Rodez, Bergerac, Toulouse as well as Brive and Carcassonne - with direct flights operated by British Airways, RyanAir, Flybe, Easyjet, Thomson, BMI and Jet2.
Full list of destinations from UK airports available on UK Airport directory
The Lot Valley is reachable within a day's travel from London St Pancras International Train Station. When you reach Paris, change then to Agen (main station in Lot-et-Garonne), Cahors (Lot), Rodez (Aveyron), Aurillac (Cantal) , Mende or Marvejols in Lozere. Count between 3 to 6 hours trip from Paris.